KEGG   Homo sapiens (human): 8989
Entry
8989              CDS       T01001                                 
Symbol
TRPA1, ANKTM1, FEPS, FEPS1, p120
Name
(RefSeq) transient receptor potential cation channel subfamily A member 1
  KO
K04984  transient receptor potential cation channel subfamily A member 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04750  Inflammatory mediator regulation of TRP channels
Disease
H01391  Familial episodic pain syndrome
Drug target
Menthol (DG01385): D00064<JP> D04849 D04918
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    8989 (TRPA1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    8989 (TRPA1)
Ion channels [BR:hsa04040]
 Voltage-gated cation channels
  Transient receptor potential channel (TRP)
   8989 (TRPA1)
SSDB
Motif
Pfam: Ank_2 Ank Ank_4 Ank_3 Ank_5 Ion_trans
Other DBs
NCBI-GeneID: 8989
NCBI-ProteinID: NP_015628
OMIM: 604775
HGNC: 497
Ensembl: ENSG00000104321
UniProt: O75762
Structure
Position
8:complement(72021250..72090010)
AA seq 1119 aa
MKRSLRKMWRPGEKKEPQGVVYEDVPDDTEDFKESLKVVFEGSAYGLQNFNKQKKLKRCD
DMDTFFLHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSR
GANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEA
LQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKA
TPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVD
IVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNL
LLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYA
CRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDL
HGMTPLHLAAKNGHDKVVQLLLKKGALFLSDHNGWTALHHASMGGYTQTMKVILDTNLKC
TDRLDEDGNTALHFAAREGHAKAVALLLSHNADIVLNKQQASFLHLALHNKRKEVVLTII
RSKRWDECLKIFSHNSPGNKCPITEMIEYLPECMKVLLDFCMLHSTEDKSCRDYYIEYNF
KYLQCPLEFTKKTPTQDVIYEPLTALNAMVQNNRIELLNHPVCKEYLLMKWLAYGFRAHM
MNLGSYCLGLIPMTILVVNIKPGMAFNSTGIINETSDHSEILDTTNSYLIKTCMILVFLS
SIFGYCKEAGQIFQQKRNYFMDISNVLEWIIYTTGIIFVLPLFVEIPAHLQWQCGAIAVY
FYWMNFLLYLQRFENCGIFIVMLEVILKTLLRSTVVFIFLLLAFGLSFYILLNLQDPFSS
PLLSIIQTFSMMLGDINYRESFLEPYLRNELAHPVLSFAQLVSFTIFVPIVLMNLLIGLA
VGDIAEVQKHASLKRIAMQVELHTSLEKKLPLWFLRKVDQKSTIVYPNKPRSGGMLFHIF
CFLFCTGEIRQEIPNADKSLEMEILKQKYRLKDLTFLLEKQHELIKLIIQKMEIISETED
DDSHCSFQDRFKKEQMEQRNSRWNTVLRAVKAKTHHLEP
NT seq 3360 nt   +upstreamnt  +downstreamnt
atgaagcgcagcctgaggaagatgtggcgccctggagaaaagaaggagccccagggcgtt
gtctatgaggatgtgccggacgacacggaggatttcaaggaatcgcttaaggtggttttt
gaaggaagtgcatatggattacaaaactttaataagcaaaagaaattaaaaagatgtgac
gatatggacaccttcttcttgcattatgctgcagcagaaggccaaattgagctaatggag
aagatcaccagagattcctctttggaagtgctgcatgaaatggatgattatggaaatacc
cctctgcattgtgctgtagaaaaaaaccaaattgaaagcgttaagtttcttctcagcaga
ggagcaaacccaaatctccgaaacttcaacatgatggctcctctccacatagctgtgcag
ggcatgaataatgaggtgatgaaggtcttgcttgagcatagaactattgatgttaatttg
gaaggagaaaatggaaacacagctgtgatcattgcgtgcaccacaaataatagcgaagca
ttgcagattttgcttaaaaaaggagctaagccatgtaaatcaaataaatggggatgtttc
cctattcaccaagctgcattttcaggttccaaagaatgcatggaaataatactaaggttt
ggtgaagagcatgggtacagtagacagttgcacattaactttatgaataatgggaaagcc
acccctctccacctggctgtgcaaaatggtgacttggaaatgatcaaaatgtgcctggac
aatggtgcacaaatagacccagtggagaagggaaggtgcacagccattcattttgctgcc
acccagggagccactgagattgttaaactgatgatatcgtcctattctggtagcgtggat
attgttaacacaaccgatggatgtcatgagaccatgcttcacagagcttcattgtttgat
caccatgagctagcagactatttaatttcagtgggagcagatattaataagatcgattct
gaaggacgctctccacttatattagcaactgcttctgcatcttggaatattgtaaatttg
ctactctctaaaggtgcccaagtagacataaaagataattttggacgtaattttctgcat
ttaactgtacagcaaccttatggattaaaaaatctgcgacctgaatttatgcagatgcaa
cagatcaaagagctggtaatggatgaagacaacgatgggtgtactcctctacattatgca
tgtagacaggggggccctggttctgtaaataacctacttggctttaatgtgtccattcat
tccaaaagcaaagataagaaatcacctctgcattttgcagccagttatgggcgtatcaat
acctgtcagaggctcctacaagacataagtgatacgaggcttctgaatgaaggtgacctt
catggaatgactcctctccatctggcagcaaagaatggacatgataaagtagttcagctt
cttctgaaaaaaggtgcattgtttctcagtgaccacaatggctggacagctttgcatcat
gcgtccatgggcgggtacactcagaccatgaaggtcattcttgatactaatttgaagtgc
acagatcgcctggatgaagacgggaacactgcacttcactttgctgcaagggaaggccac
gccaaagccgttgcgcttcttctgagccacaatgctgacatagtcctgaacaagcagcag
gcctcctttttgcaccttgcacttcacaataagaggaaggaggttgttcttacgatcatc
aggagcaaaagatgggatgaatgtcttaagattttcagtcataattctccaggcaataaa
tgtccaattacagaaatgatagaatacctccctgaatgcatgaaggtacttttagatttc
tgcatgttgcattccacagaagacaagtcctgccgagactattatatcgagtataatttc
aaatatcttcaatgtccattagaattcaccaaaaaaacacctacacaggatgttatatat
gaaccgcttacagccctcaacgcaatggtacaaaataaccgcatagagcttctcaatcat
cctgtgtgtaaagaatatttactcatgaaatggttggcttatggatttagagctcatatg
atgaatttaggatcttactgtcttggtctcatacctatgaccattctcgttgtcaatata
aaaccaggaatggctttcaactcaactggcatcatcaatgaaactagtgatcattcagaa
atactagataccacgaattcatatctaataaaaacttgtatgattttagtgtttttatca
agtatatttgggtattgcaaagaagcggggcaaattttccaacagaaaaggaattatttt
atggatataagcaatgttcttgaatggattatctacacgacgggcatcatttttgtgctg
cccttgtttgttgaaataccagctcatctgcagtggcaatgtggagcaattgctgtttac
ttctattggatgaatttcttattgtatcttcaaagatttgaaaattgtggaatttttatt
gttatgttggaggtaattttgaaaactttgttgaggtctacagttgtatttatcttcctt
cttctggcttttggactcagcttttacatcctcctgaatttacaggatcccttcagctct
ccattgctttctataatccagaccttcagcatgatgctaggagatatcaattatcgagag
tccttcctagaaccatatctgagaaatgaattggcacatccagttctgtcctttgcacaa
cttgtttccttcacaatatttgtcccaattgtcctcatgaatttacttattggtttggca
gttggcgacattgctgaggtccagaaacatgcatcattgaagaggatagctatgcaggtg
gaacttcataccagcttagagaagaagctgccactttggtttctacgcaaagtggatcag
aaatccaccatcgtgtatcccaacaaacccagatctggtgggatgttattccatatattc
tgttttttattttgcactggggaaataagacaagaaataccaaatgctgataaatcttta
gaaatggaaatattaaagcagaaataccggctgaaggatcttacttttctcctggaaaaa
cagcatgagctcattaaactgatcattcagaagatggagatcatctctgagacagaggat
gatgatagccattgttcttttcaagacaggtttaagaaagagcagatggaacaaaggaat
agcagatggaatactgtgttgagagcagtcaaggcaaaaacacaccatcttgagccttag

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Drug (3)   
   KEGG DRUG (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (30)   
   KEGG ORTHOLOGY (1)   
   RefGene (24)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (7)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (5)   
DNA sequence (9)   
   RefSeq(nuc) (5)   
   GenBank (2)   
   EMBL (2)   
3D Structure (14)   
   PDB (14)   
Protein domain (6)   
   Pfam (6)   
All databases (76)   

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